Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are a group of emerging highly drug-resistant Gram-negative bacilli causing infections associated with significant morbidity and mortality.
Table of Contents
What is a KPC producing organisms?
Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are a group of emerging highly drug-resistant Gram-negative bacilli causing infections associated with significant morbidity and mortality.
What bacteria produces carbapenemase?
What is Carbapenemase-Producing Organisms (CPO)? CPO refers to bacteria such as Klebsiella, Escherichia coli (E. coli), Acinetobacter, and Pseudomonas, that are found in normal human intestines.
How is KPC production detected?
For the recognition of KPCs, have been established several phenotypic tests (12, 25). The method presently approve by the CLSI is the modified Hodge test (MHT) and this method is accepted as a specific and sensitive method for detection of carbapenemase (26, 27).
Is KPC and CRE the same?
The term CRE refers to carbapenem-resistant and carbapenemase-producing Enterobacteriaceae. Currently, the most common type of carbapenemase in the United States is the Klebsiella pneumoniae carbapenemase (KPC).
What is KPC Where does it live?
The bugs raising alarm are called KPC (Klebsiella pneumoniae carbapenemase) or CRE (carbapenem-resistant Enterobacteriaceae). The Enterobacteriaceae (pronounced enter-oh-bact-ear-ee-ay-cee-ee) are a large family of bacteria, which largely live as a normal part of people’s healthy gut bacteria.
Is KPC a gene?
The Klebsiella pneumoniae carbapenemase (KPC) enzyme, encoded by alleles of the bla KPC gene, represents one of the five major carbapenemase families, others being the VIM, IMP and NDM metallo-beta-lactamases, and the OXA-48-like oxacillinases3.
What are the symptoms of KPC?
Klebsiella pneumoniae symptoms
- fever.
- chills.
- coughing.
- yellow or bloody mucus.
- shortness of breath.
- chest pain.
How is CPO transmitted?
CPO are transmitted from person to person by direct and indirect contact. These organisms are most likely to be acquired through healthcare exposures related to poor hand hygiene and contaminated patient equipment. CPO prevalence is increasing worldwide, including in the United States.
What do Carbapenemases do?
Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria producing these β-lactamases may cause serious infections in which the carbapenemase activity renders many β-lactams ineffective.
How do you treat KPC?
What molecules can be used to treat KPC-KP infections? Various molecules can be used in combination treatment against KPC-KP, including aminoglycosides, polymyxins, tigecycline, fosfomycin, ceftazidime/avibactam and carbapenems in selected cases (see Table 2).
Where is KPC usually found?
Klebsiella bacteria are normally found in the human intestines (where they do not cause disease). They are also found in human stool (feces). In healthcare settings, Klebsiella infections commonly occur among sick patients who are receiving treatment for other conditions.