Is CD90 a fibroblast marker?
CD90 is also found on mesenchyme within tumors that promote tumor growth (True et al., 2010). Based on CD90s expression on various mesenchyme cell types it has been considered as a defining fibroblastic marker (Katsumata et al., 2017). Fibroblasts were originally described as a single cell type (Ramon y Cajal, 1900).
What is CD90 a marker for?
CD90 as a Cancer Stem Cell Marker The ability to form tumors in vivo in immunodeficient mice is considered to be one of the most important properties of CSCs.
What are CD90+ cells?
Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen.
Do B cells express CD90?
We show here, however, that in contrast to adult MZ-B cells, MZ-B cells (and also recirculating follicular (RF)-B cells) in neonatal rats express higher levels of CD90 (Thy-1). In adult rats, expression of CD90 on the B cell lineage is confined to immature B cells.
Do macrophages express CD90?
Specifically, MSCs expressed high levels of surface CD90 and were negative for CD14 cell surface marker, while macrophages expressed an opposite pattern. MSCs derived from BM could differentiate into bone, fat and cartilage in vitro, using appropriate growth factors (data not shown).
Is vimentin a cell surface marker?
Cell surface markers have been identified for isolating cancer stem-like cells, but none has been identified for isolating cancer stem-like cells with EMT phenotype. Recently, we discovered that Vimentin, an intracellular EMT tumor cell marker, is present on the surface of colon metastatic tumor nodules in the liver.
Do T cells express CD90?
CD90 is expressed on a subset of T cells 1A, 1B). This GPI-anchored protein has been described to be present on a small population of human mature CD4+ T cells (1). Then, we further analyzed CD90 expression in CD4+ and CD8+ T cells from freshly isolated PBMCs (MNCs) of healthy donors.
Do NK cells express CD90?
Developmental and Activation States of Group 1 ILCs. Collective reports have demonstrated that iNK cells in mouse bone marrow and periphery can express Ly49 receptors, CD49a, CD90, TRAIL, CD69, and Eomes, and lack CD49b expression (3, 21, 29–31).
What CD is on macrophages?
In humans, CD antigens include CD14, CD312, CD115, and CD16. Subset-specific markers include CD163 and CD204, both scavenger receptors expressed by M2 macrophages, CD301, and CD206.
Is CD45 expressed on macrophages?
CD45 and LSP-1 are expressed by all hematopoietic cells including lymphocytes, monocytes, macrophages, and fibrocytes [16], [25], [26].