What causes elevated PTHrP?
An increased level of PTH-related protein with a high blood calcium level is usually caused by cancer. PTH-related protein can be produced by many different kinds of cancers, including those of the lung, breast, head, neck, bladder, and ovaries.
What is a normal level of PTHrP?
Mean serum PTHrP levels were 4.9 ± 0.5 pmol/L (normal, <2.5) and values above the normal range were found in 53% of the patients (76% in lung and upper respiratory tract malignancies).
Is PTHrP elevated in multiple myeloma?
PTHrP has been measured as elevated in the plasma of patients with myeloma and might be an important contributor to the skeletal complications in this disease.
What does PTHrP test for?
Measurement of parathyroid hormone-related peptide (PTHrP) is often requested for patients with hypercalcemia before confirmation of hypercalcemia and/or determination of parathyroid hormone (PTH) concentrations. We determined a PTH cutoff to guide PTHrP testing in hypercalcemic patients.
Does PTHrP cause hypophosphatemia?
PTHrP is structurally similar to PTH and, like PTH, it enhances renal tubular reabsorption of calcium while simultaneously increasing urinary phosphorus excretion. The result is both hypercalcemia and hypophosphatemia.
What cancers cause high calcium in urine?
Patients with breast cancer, lung cancer, and myeloma are most commonly affected, but hypercalcemia can also occur with other malignancies, including renal, gynecologic, and head and neck cancers.
Can multiple myeloma cause hyperparathyroidism?
Abstract. Hypercalcemia is a significant feature of patients with active multiple myeloma (MM) with extensive bone disease. Among the causes of non-neoplastic hypercalcemia, primary hyperparathyroidism (PHPT) is one of the most common, leading to osteoporosis and bone fractures.
Is parathyroid hormone A protein?
Parathyroid hormone-related protein (PTHrP) is actually a family of protein hormones produced by most if not all tissues in the body.
What causes low PTHrP?
When the parathyroid glands produce too little PTH, blood levels of calcium fall and phosphorous levels rise. The most common cause of hypoparathyroidism is injury to the parathyroid glands during thyroid or neck surgery.
What does a low PTHrP mean?
Low – order PTH-related peptide (PTHrP) High PTHrP – consider cancer. Low or normal PTHrP – order vitamin D, 1,25-dihydroxy [1,25-(OH)2-D] High 1,25-(OH)2-D – consider lymphoma or granulomatous disease. Low or normal 1,25-(OH)2-D – consider vitamin D excess, cancer, milk-alkali syndrome, or hyperthyroidism.
What can cause a false positive PTHrP blood test?
Children and young adults may also test temporarily high when given the PTHrP blood test. This is because tooth eruption tends to spike the results. A rare issue that sometimes happens is that the presence of heterophile antibodies can cause a false positive result. This may happen after a viral infection or disease, such as rheumatic fever.
Does a positive PTHrP test mean cancer?
The PTHrP Blood Test Is Not Used For Screening. Just because you have a positive PTHrP blood test does not automatically mean that you have cancer. About 80% of people who have a malignant tumor and high levels of calcium and from that group, about half will have a positive blood test result.
What happens if you don’t have PTH/PTHrP receptors?
Without PTHrP teeth will not erupt and become impacted in early life. PTHrP has also a function in the growth of the hair follicle. Antagonsts of the PTH/PTHrP receptor stimulate the proliferation of hair follicle cells and may be used in the future for chemotherapy-induced alopecia.
Is PTH-rP elevated in renal failure?
The elevated C-terminal PTH-RP assay was clinically thought to be falsely elevated in this patient with renal failure and hypercalcemia, and no further studies for malignancy were undertaken.