What does HMB 45 positive mean?

What does HMB 45 positive mean?

The presence of one or two isolated HMB-45–positive cells may pose diagnostic difficulty in differentiating isolated melanoma cells from melanophages and benign cells showing melanocytic differentiation, such as nevus cells in lymph nodes (19).

How long can a dog live with benign melanoma?

Tumors less than two centimeters without spread (stage I) can have survival times of 15-18 months on average with surgery alone. Once tumors are two cm or larger, the prognosis with surgery alone decreases.

Can melanoma be cured in dogs?

Dogs treated with surgery alone to remove a malignant melanoma, even if the surgical removal is complete, typically develop metastatic disease within 5-6 months of surgery. Only about 10% of dogs will survive more than a year with surgery alone as treatment.

What is desmoplastic melanoma?

Desmoplastic melanoma is a rare form of the disease that accounts for around 4 percent of all skin melanomas. The main sign of desmoplastic melanoma is a spot that may look like a scar in texture and appearance. It tends to develop on the face, scalp, neck, and sun-exposed areas of the arms and legs.

What does s100 positive mean?

S-100 protein (S-100B) is the most widely used marker for peripheral nerve sheath tumors. Although S-100 protein is positive in all benign Schwann cell tumors, this marker shows relatively low sensitivity for MPNST (at most, around 50%).

Is uveal melanoma fatal in dogs?

1,2 Uveal melanomas are considered benign in this species, although metastasis has rarely been reported.

How do dogs get malignant melanoma?

Melanoma is a cancer that happens as a result of the unregulated proliferation of melanocytes, a pigment-carrying cell that resides in mammalian skin and mucous membranes. Older dogs are especially prone to this cancer, particularly to its highly aggressive oral form.

How serious is desmoplastic melanoma?

Desmoplastic melanoma is highly curable when diagnosed early. The goals for treatment of desmoplastic melanoma are to: cure the cancer. preserve the appearance of your skin.

How aggressive is desmoplastic melanoma?

The locally aggressive nature of DM is a common theme in the literature. In our series, the lesions had a mean Breslow thickness of 5.09 mm and a 21% incidence of local recurrence. The incidence of local recurrence for DM reported in the literature has ranged from 11% to 40%.