What does inhibin A test for?
Inhibin A Test is a basic blood test that measure the level Inhibin A in the blood. It is used in pregnant women who are suspected of carrying a foetus with down syndrome. The Inhibin A test is also used for the diagnosis of Granulosa cell tumours and Mucinous Epithelial Ovarian Tumour.
What does high inhibin A mean?
High levels of maternal serum inhibin-A in the second trimester are significantly associated with abnormal placentation, which increases the risk of preeclampsia and FGR with a consequence of indicated preterm birth but not a risk of spontaneous preterm birth.
What is the normal level of inhibin A during pregnancy?
Serum concentrations of inhibin A in women with normal pregnancies rise to a median of about 550 pg per milliliter at 8 to 9 weeks’ gestation, followed by a decline that levels out at about 180 pg per milliliter at 15 weeks’ gestation.
Does high inhibin A always mean Down syndrome?
An inhibin A level > or = 1.6 multiples of the median identified 70% of all Down syndrome pregnancies at a false-positive rate of 22%. Replacing estriol with inhibin A in the multiple-marker screening test resulted in a higher Down syndrome detection rate at a lower screen-positive rate.
What is inhibin a tumor marker?
Functional inhibin is secreted by all granulosa cell tumours of the ovary studied and can be used as a tumour marker to determine response to therapy and predict recurrence and is superior to oestradiol.
What does inhibin A and B test for?
Inhibin A and/or inhibin B tests may be used along with a test for CA-125 to help determine whether you have an ovarian tumor. Testing may also be used to help diagnose a rare type of ovarian tumor called a granulosa cell tumor, and less commonly used to help diagnose a mucinous epithelial ovarian tumor.
What is a normal range for inhibin A?
The normal range of inhibin in post-menopausal women is < 5 pg ml-1, in pre-menopausal women 2-80 pg ml-1 (2-10 pg ml-1 in the follicular phase, 40-80 pg ml-1 in the luteal phase).
What is the function of inhibin?
Abstract. Inhibin is a protein secreted by the Sertoli cells in men and by the granulosa cells in women. It inhibits the synthesis and release of the follicle-stimulating hormone in the pituitary gland and reduces the hypothalamic LH – releasing hormone content.
What causes high inhibin in pregnancy?
The level of elevated Inhibin A in pregnancy is significantly related to the outcome of pre-eclampsia, GDM, macrosomia, low birth weight and preterm delivery.
What causes high inhibin A in pregnancy?
What is PAPP-A mom?
This means it is unique to the current pregnancy. PAPP-A stands for Pregnancy Associated Plasma Protein-A. In the early weeks of pregnancy, the placenta forms and embeds itself onto the wall of the uterus. By the time of the 12 week scan the placenta is made and PAPP-A can be found in the mother’s blood.
What does inhibin positive mean?
Elevated levels of inhibin A and/or inhibin B may be present in the blood of a woman with a rare type of ovarian tumor called a granulosa cell tumor (the most common type of sex-cord stromal tumor). Blood levels of these hormones may also be elevated in some women with mucinous epithelial tumors.