What is Biacore analysis?
Biacore is used by BioAgilytix in immunogenicity studies to analyze and characterize anti-drug antibodies (ADAs) and molecular interactions related kinetics, specificity, and concentration.
What does surface plasmon resonance tell us?
Surface plasmon resonance (SPR) allows real-time, label-free detection of biomolecular interactions. SPR occurs when polarized light strikes an electrically conducting surface at the interface between two media.
What is a Sensorgram?
sensorgram (plural sensorgrams) A graph of responses versus time in surface plasmon resonance studies.
What is Surface Plasmon theory?
Surface plasmons (SPs) are coherent delocalized electron oscillations that exist at the interface between any two materials where the real part of the dielectric function changes sign across the interface (e.g. a metal-dielectric interface, such as a metal sheet in air).
What is surface plasmon effect?
Surface plasmon resonance (SPR) is the manifestation of a resonance effect due to the interaction of conduction electrons of metal nanoparticles with incident photons. The interaction relies on the size and shape of the metal nanoparticles and on the nature and composition of the dispersion medium.
How is surface plasmon resonance used?
SPR is the basis of many standard tools for measuring adsorption of material onto planar metal (typically gold or silver) surfaces or onto the surface of metal nanoparticles. It is the fundamental principle behind many color-based biosensor applications, different lab-on-a-chip sensors and diatom photosynthesis.
What is surface plasmon resonance for dummies?
Surface plasmon resonance (SPR) is the collective oscillation of conduction band electrons that are in resonance with the oscillating electric field of incident light, which will produce energetic plasmonic electrons through non-radiative excitation.
What is Biacore assay?
Biacore Assay Handbook 29-0194-00 Edition AA7 Introduction 1 1.5 Biacore terminology Biacore systems monitor the interaction between two molecules, of which one is attached to the sensor surface and the other is free in solution.
What are the components of a Biacore sensor?
The sensor chip in Biacore systems consists of a glass slide coated with a thin layer of gold. These components, together with the docking system for mounting the sensor chip in the optical system, are required for generation of an SPR signal.
What is sensorgram comparison?
well as the use of Sensorgram Comparison, a statistical tool incorporated in Biacore T200 Software v3.0. This software functionality enables quantitative assessment of comparability of complex kinetic data directly from curve
What is Biacore comparability tool?
Biacore comparability tool for quantitating binding similarities in IgG Fcγ receptor analysis Biacore comparability tool for quantitating binding similarities in IgG Fcγ receptor analysis Intellectual Property Notice: The Biopharma business o f GE Healthcare was acquired by Danaher on 31 March 2020