Digibind is indicated for the treatment of potentially life-threatening digoxin intoxication. The manifestations of life-threatening digoxin toxicity include ventricular arrhythmias such as ventricular tachycardia or ventricular fibrillation or profound and progressive bradyarrhythmias not responsive to atropine.
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What is Digibind used for?
Digibind is indicated for the treatment of potentially life-threatening digoxin intoxication. The manifestations of life-threatening digoxin toxicity include ventricular arrhythmias such as ventricular tachycardia or ventricular fibrillation or profound and progressive bradyarrhythmias not responsive to atropine.
What is DigiFab used for?
DigiFab is a prescription medicine used to treat the symptoms of toxicity after Acute Ingestion and toxicity during Chronic Therapy. DigiFab may be used alone or with other medications. DigiFab belongs to a class of drugs called Antidotes, Other.
Where were MGBs made?
Australia
The MGB was assembled in Australia from 1963 to 1972, during which time approximately 9,000 were sold. The cars were assembled from complete knock down kits shipped from England.
How is DigiFab administered?
DigiFab should be administered slowly as an intravenous infusion over at least 30 minutes. If infusion rate-related reactions occur, the infusion should be stopped and re-started at a slower rate. If cardiac arrest is imminent, DigiFab can be given by bolus injection.
Is Digibind still made?
The Digibind brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
When should Digibind be given?
DIGIBIND, Digoxin Immune Fab (Ovine), is administered by the intravenous route over 30 minutes. It is recommended that it be infused through a 0.22-micron membrane filter to ensure no undissolved particulate matter is administered. If cardiac arrest is imminent, it can be given as a bolus injection.
What is the antidote for benzodiazepines?
Medication Summary Flumazenil is a selective competitive antagonist of the gamma-aminobutyric acid (GABA) receptor and is the only available specific antidote for benzodiazepine (BZD) toxicity. It will reverse the effects of BZDs but must be used with caution.
How many Mgbs are still on the road?
The MG MGB was first introduced on the market in 1963 by the British Motor Corporation and ceased production in 1980, although a limited re-release was issued between 1992 and 1995. By the end of 2018, the number of registered MGB models had net declined to 21,236 units.
How fast does DIGIFab work?
In a comparative pharmacokinetic study of DIGIFab and Digibind administered in healthy volunteers, DIGIFab rapidly reduced serum free digoxin to undetectable levels within 30 minutes, and serum digoxin levels were reduced to undetectable levels in all subjects.
How long does it take for Digibind to work?
Ordinarily, following administration of DIGIBIND (digoxin immune fab) , improvement in signs and symptoms of digitalis intoxication begins within one-half hour or less.