Where does apoptosis occur during normal development?

Apoptosis occurs in normal tissue turnover, in organ involution after withdrawal of trophic hormones, in distinct cells after deprivation of growth factors or specific stimuli and in cells which have undergone sublethal damage.

Where does apoptosis occur during normal development?

Apoptosis occurs in normal tissue turnover, in organ involution after withdrawal of trophic hormones, in distinct cells after deprivation of growth factors or specific stimuli and in cells which have undergone sublethal damage.

What is the role of apoptosis in normal healthy development?

Role of Apoptosis in Health and Disease Apoptosis occurs during the normal development of multicellular organisms and continues throughout adult life. The combination of apoptosis and cell proliferation is responsible for shaping tissues and organs in developing embryos.

What is apoptosis and how does it play a role in development?

Programmed cell death plays an important role in the processes of gamete maturation as well as in embryo development, contributing to the appropriate formation of various organs and structures. Apoptosis is one of the mechanisms of action of various cytotoxic agents and teratogens.

Is apoptosis normal or pathological?

Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health.

How does apoptosis aid in normal embryo?

How does apoptosis aid in normal embryo development? It helps sculpt body parts by removing unnecessary cells.

Is apoptosis a part of morphogenesis?

In particular, it has long been acknowledged that apoptosis participates in tissue remodeling. Yet, until recently, this contribution to morphogenesis was considered as “passive,” consisting simply in the local removal of unnecessary cells leading to a new shape.

What is the role of apoptosis?

Apoptosis is the process of programmed cell death. It is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also plays a role in preventing cancer.

Is apoptosis necessary for brain development?

Apoptosis occurs extensively during the normal development of the mammalian nervous system and has been observed in populations of developing neural precursor cells, differentiated postmitotic neurons and glial cells. These cell deaths are important for establishing neuronal and glial populations of the correct size.

Is apoptosis physiological or pathological?

Apoptosis is a physiological process of cell death by which a single cell may be eliminated from the living tissue. Since the process is mediated by specific proteins encoded in the host’s genome, it is also a programmed cell death.

What is the effect of apoptosis during mammalian development?

Cells may be over produced during embryonic development, and apoptosis helps to control this. During mammalian development, apoptosis also aids in quality control, through removal of irregular, non-functional or dangerous cells, and preventing birth defects and cancer (Jacobson et al., 1997).

Why is apoptosis important for homeostasis?

Apoptosis is mainly active during embryonic development, when deletion of redundant cellular material is required for the correct morphogenesis of tissues and organs; moreover, it is essential for the maintenance of tissue homeostasis during cell life.

What apoptosis means?

(A-pop-TOH-sis) A type of cell death in which a series of molecular steps in a cell lead to its death. This is one method the body uses to get rid of unneeded or abnormal cells. The process of apoptosis may be blocked in cancer cells. Also called programmed cell death.